# Corpus Correction Ledger — PRISM and Neurotechnology — 2026-09-11 **Scope:** PRISM acronym resolution, E11 Bio naming and publication status, the digital-minds charity chronology, registry metadata, and the UNESCO neurotechnology-adoption record. **Collections:** [[collections/Neurotech|Neurotech]] · [[collections/Consciousness Continuity|Consciousness Continuity]] **Source articles reviewed:** [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]] · [[articles/Mind Uploading and AI — The Host is Reusable and the Person is the Delta|Mind Uploading and AI — The Host is Reusable and the Person is the Delta]] · [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] · [[articles/The Architecture of Continuity and Emerging Neuroinformatics Standards|The Architecture of Continuity and Emerging Neuroinformatics Standards]] · [[articles/Host-Indexed Autonomy|Host-Indexed Autonomy]] ## Corrections ### PRISM expansion - **Canonical publication form:** **Protein-barcode Reconstruction via Iterative Staining with Molecular annotations**. The September 28, 2025 bioRxiv preprint is controlling for the name of the published platform. - **Documented variant:** **Protein-barcode Reconstruction by Iterative Staining with Molecular annotations**. E11's December 2024 roadmap and Addgene use this wording. - **Conflicting registry metadata:** **Protein Reconstruction and Identification through Multiplexing**. The AWS Open Data registry and the E11 PRISM training-repository README currently use this wording. It remains a source-attributed discrepancy rather than an accepted synonym. - **Excluded wording:** **Photo-connectomic Reconstruction by Iterative Staining with Molecular annotations**. No verified E11 source reviewed in this pass connects that wording to the project. ### Publication and capability boundaries - The September 2025 PRISM paper is a **preprint**, not a peer-reviewed journal article. - The demonstrated dataset is an approximately **10-million-µm³ mouse hippocampal CA2/3 pilot**, not a whole mouse brain or human connectome. - The reported eightfold increase concerns automatic tracing accuracy from combined barcode segmentation and proofreading. It does not establish perfect or error-free reconstruction. - The approximately **35 × 35 × 80 nm** measurements are effective voxel dimensions after expansion, not a synonym for optical resolution. - Whole-brain mapping, brain simulation, NeuroAI, therapeutics, BCI, and 100-fold cost reduction remain dated developer roadmaps or projections pending independent large-volume replication. ### Partnership for Research Into Sentient Machines chronology - UK charity **1184317** was registered as a Charitable Incorporated Organisation on **8 July 2019** and previously operated as **The Economic Singularity Foundation**. - The public PRISM identity launched on **17 March 2025** around an AI UK workshop. The 2019 legal origin and 2025 PRISM launch are distinct date-significant facts. - Conscium publicly states that it launched PRISM and supplied its initial funding. That supports a seed/founding-support edge and personnel overlap, not organizational identity or ownership. - Cambridge Digital Minds, Rethink Priorities, Neuromatch, the Institute of Neuroethics, and PRISM have program-specific documented relationships. PRISM's wider field map is a discovery index, not proof that every listed organization is a formal partner. - The digital-minds charity is unrelated to [[wiki/PRISM (E11 Bio)|PRISM (E11 Bio)]] and [[wiki/PRISM (NSA)|PRISM (NSA)]]. ### UNESCO adoption procedure and date - UNESCO's **Recommendation on the Ethics of Neurotechnology** was adopted **by acclamation** at the 43rd General Conference on **November 11, 2025**. - The official plenary record states that the president proposed adoption by acclamation, observed no objections, and declared the decision; the SHS Commission record likewise states adoption by acclamation. - This parliamentary act is not equivalent to a recorded proposition that each of UNESCO's 194 Member States individually cast an affirmative vote. ## Relationships - **Corrects and routes:** [[wiki/PRISM|PRISM]], [[wiki/PRISM (E11 Bio)|PRISM (E11 Bio)]], [[wiki/PRISM (Partnership for Research Into Sentient Machines)|PRISM (Partnership for Research Into Sentient Machines)]], [[wiki/PRISM (NSA)|PRISM (NSA)]], [[wiki/E11 Bio|E11 Bio]], [[wiki/Neurorights|Neurorights]], and [[wiki/UNESCO Recommendation on the Ethics of Neurotechnology|UNESCO Recommendation on the Ethics of Neurotechnology]]. - **Evidence boundary:** direct paper claims, developer claims, registry metadata, and interpretive continuity relevance remain separately labeled. - **Collection route:** [[collections/Neurotech|Neurotech]]. ## Sources - [bioRxiv — PRISM preprint](https://doi.org/10.1101/2025.09.26.678648) - [E11 Bio — PRISM release](https://www.e11.bio/blog/prism) - [E11 Bio — 2024 roadmap](https://www.e11.bio/blog/roadmap) - [Addgene — E11 Bio PRISM Collection](https://www.addgene.org/depositor-collections/e11-bio-prism-collection/) - [AWS Registry of Open Data — E11bio PRISM](https://registry.opendata.aws/e11bio-prism/) - [UK Charity Commission — PRISM governance](https://register-of-charities.charitycommission.gov.uk/charity-search/-/charity-details/5135848/governance) - [PRISM — Confronting a Future with Conscious Machines](https://www.prism-global.com/blog/prism-confronting-a-future-with-conscious-machines) - [Conscium — Conscium launches PRISM](https://conscium.com/blog/conscium-launches-prism-a-non-profit-dedicated-to-researching-sentient-ai) - [Cambridge Digital Minds — Fellowship Programme](https://digitalminds.cam/fellowship/) - [Neuromatch — AI Sentience Scholars](https://neuromatch.io/ai-sentience-scholars/) - [UNESCO — 43rd General Conference plenary record](https://www.unesco.org/sites/default/files/medias/fichiers/2025/11/43-VR-13-init-multilangue-unedited.pdf)