# New Species Begin When Populations Evolve Apart by David C. Queller > “Formation of new biological species usually involves isolation and independent evolution of the two populations. As one toad population evolves through natural selection, each of its novel genes is tried out in many toads and will necessarily be selected to work together with the other genes in its population. Any genes causing within-population mismatches are weeded out. But, novel genes in one toad population are never tested with novel genes in another isolated toad population. Between-population mismatches will not be weeded out and will gradually accumulate, becoming apparent only when the populations later come into contact.” > **— David C. Queller**, *2017, Edge Annual Question, “What Scientific Term Or Concept Ought To Be More Widely Known?”* ## Sources and Context - **Direct Edge response and surrounding essay:** [Isolation Mismatch](https://www.edge.org/response-detail/27152) — Edge published this exact passage in its 2017 Annual Question collection, *WHAT SCIENTIFIC TERM OR CONCEPT OUGHT TO BE MORE WIDELY KNOWN?*. The response page preserves the surrounding argument and qualifications. - **Complete local collection index:** [[research/Edge 2017 Full Quotation Curation|Edge 2017 Full Quotation Curation]] — retained source-first record for the complete response cohort and this passage's promotion status. ## Related Articles and Collections - **Collection:** [[collections/Edge|Edge]] - **Collection:** [[collections/Machine Succession|Machine Succession]] - **Article:** [[articles/The Evolutionary Roots of Silicon Valley|Valley Roots]] - **Article:** [[articles/Digital Darwinism and the Invisible World of Machine Evolution|Digital Darwinism]] - **Article:** [[articles/We Were Never Going to Make It|Never Going to Make It!]] - **Wiki map:** [[wiki/Evolutionary Biology|Evolutionary Biology]] ## Related Topics - [[wiki/Evolutionary Biology|Evolutionary Biology]] - [[wiki/Population Genetics|Population Genetics]] - [[wiki/Molecular Evolution|Molecular Evolution]] - [[wiki/Epigenetic|Epigenetic]] ## Share on Social Media ``` “Formation of new biological species usually involves isolation and independent evolution of the two populations. As one toad population evolves through natural selection, each of its novel genes is tried out in many toads and will necessarily be selected to work together with the other genes in its population. Any genes causing within-population mismatches are weeded out. But, novel genes in one toad population are never tested with novel genes in another isolated toad population. Between-population mismatches will not be weeded out and will gradually accumulate, becoming apparent only when the populations later come into contact.” — David C. Queller, 2017, Edge Annual Question, “What Scientific Term Or Concept Ought To Be More Widely Known?” https://bryantmcgill.com/simple-reminders-david-queller-new-species-begin-populations-evolve ```