# The Rise in Genomic Instability by Eric Topol > “Although we now have an appreciation for the frequency of de novo mutations due to the spectacular advances in sequencing technology and analytics, we do not have even a rudimentary understanding of what induces them in the first place—and what are the more subtle impacts that may track with a sort of devolution of man. Especially disconcerting is that the signals of increased genomic instability are occurring in a relatively short span of time, in the context of human evolution over millions of years.” > **— Eric Topol**, *2013, Edge Annual Question, “What *should* We Be Worried About?”* ## Sources and Context - **Direct Edge response and surrounding essay:** [The Rise In Genomic Instability](https://www.edge.org/response-detail/23703) — Edge published this exact passage in its 2013 Annual Question collection, *WHAT *SHOULD* WE BE WORRIED ABOUT?*. The response page preserves the surrounding argument and qualifications. - **Complete local collection index:** [[research/Edge 2013 Full Quotation Curation|Edge 2013 Full Quotation Curation]] — retained source-first record for the complete response cohort and this passage's promotion status. ## Related Articles and Collections - **Collection:** [[collections/Edge|Edge]] - **Collection:** [[collections/Machine Succession|Machine Succession]] - **Article:** [[articles/The Evolutionary Roots of Silicon Valley|Valley Roots]] - **Article:** [[articles/Digital Darwinism and the Invisible World of Machine Evolution|Digital Darwinism]] - **Article:** [[articles/We Were Never Going to Make It|Never Going to Make It!]] - **Wiki map:** [[wiki/Evolutionary Biology|Evolutionary Biology]] ## Related Topics - [[wiki/Evolutionary Biology|Evolutionary Biology]] - [[wiki/Gene-Culture Coevolution|Gene-Culture Coevolution]] - [[wiki/Cultural Evolution|Cultural Evolution]] - [[wiki/Human Evolution|Human Evolution]] ## Share on Social Media ``` “Although we now have an appreciation for the frequency of de novo mutations due to the spectacular advances in sequencing technology and analytics, we do not have even a rudimentary understanding of what induces them in the first place—and what are the more subtle impacts that may track with a sort of devolution of man. Especially disconcerting is that the signals of increased genomic instability are occurring in a relatively short span of time, in the context of human evolution over millions of years.” — Eric Topol, 2013, Edge Annual Question, “What *should* We Be Worried About?” https://bryantmcgill.com/simple-reminders-eric-topol-rise-genomic-instability ```