# Natural Selection Builds Unimaginably Complex Systems by Randolph Nesse > “Natural selection shapes systems whose complexity is indescribable in terms satisfying to human minds. Some may feel this is nihilistic. It does discourage hopes for finding simple specific descriptions for all biological systems. However, recognizing a quest as hopeless is often the key to progress. As Haldane put it, "We are thus brought face-to-face with the conclusion which to the biologist is just as significant and fundamental, just as true to the facts observed, as the conclusion of mass persists is to the physicists… the structure of a living organism has no real resemblance in its behavior to that of a machine… In the living organisms…the "structure" is only the appearance given by what seems at first to be a constant flow of specific material, beginning and ending in the environment."” > **— Randolph Nesse**, *2012, Edge Annual Question, “What Is Your Favorite Deep, Elegant, Or Beautiful Explanation?”* ## Sources and Context - **Direct Edge response and surrounding essay:** [Natural Selection Is Simple, But The Systems It Shapes Are Unimaginably Complex](https://www.edge.org/responses/what-is-your-favorite-deep-elegant-or-beautiful-explanation) — Edge published this exact passage in its 2012 Annual Question collection, *WHAT IS YOUR FAVORITE DEEP, ELEGANT, OR BEAUTIFUL EXPLANATION?*. The response page preserves the surrounding argument and qualifications. - **Complete local collection index:** [[research/Edge 2012 Full Quotation Curation|Edge 2012 Full Quotation Curation]] — retained source-first record for the complete response cohort and this passage's promotion status. ## Related Articles and Collections - **Collection:** [[collections/Edge|Edge]] - **Collection:** [[collections/Machine Succession|Machine Succession]] - **Article:** [[articles/The Evolutionary Roots of Silicon Valley|Valley Roots]] - **Article:** [[articles/Digital Darwinism and the Invisible World of Machine Evolution|Digital Darwinism]] - **Article:** [[articles/We Were Never Going to Make It|Never Going to Make It!]] - **Wiki map:** [[wiki/Evolutionary Biology|Evolutionary Biology]] ## Related Topics - [[wiki/Evolutionary Biology|Evolutionary Biology]] - [[wiki/Unit of Selection|Unit of Selection]] - [[wiki/Selection Gradient|Selection Gradient]] - [[wiki/Evolutionary Dynamics|Evolutionary Dynamics]] ## Share on Social Media ``` “Natural selection shapes systems whose complexity is indescribable in terms satisfying to human minds. Some may feel this is nihilistic. It does discourage hopes for finding simple specific descriptions for all biological systems. However, recognizing a quest as hopeless is often the key to progress. As Haldane put it, "We are thus brought face-to-face with the conclusion which to the biologist is just as significant and fundamental, just as true to the facts observed, as the conclusion of mass persists is to the physicists… the structure of a living organism has no real resemblance in its behavior to that of a machine… In the living organisms…the "structure" is only the appearance given by what seems at first to be a constant flow of specific material, beginning and ending in the environment."” — Randolph Nesse, 2012, Edge Annual Question, “What Is Your Favorite Deep, Elegant, Or Beautiful Explanation?” https://bryantmcgill.com/simple-reminders-randolph-nesse-natural-selection-builds-unimaginably-complex ```