Andrew C. Payne - Bryant McGill

# Andrew C. Payne **Entity class:** Researcher and research-program author **Collection:** [[collections/Neurotech|Neurotech]] **Canonical source article:** [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] ## Definition **Andrew C. Payne** is E11 Bio's co-founder and CEO and author of the organization’s published roadmap for scaling connectomics to mammalian brains. The roadmap identifies proofreading labor as the dominant cost center and presents [[wiki/PRISM (E11 Bio)|PRISM]] as E11 Bio’s route toward lower-cost optical reconstruction. His earlier MIT research joined sequencing chemistry and imaging, a technical lineage relevant to PRISM's multiplexed molecular readout. The preprint credits him with conceptualization, methodology, software, validation, investigation, writing, visualization, supervision, project administration, and funding acquisition. ## Relationships - **Organization:** [[wiki/E11 Bio|E11 Bio]]. - **Program:** [[wiki/PRISM (E11 Bio)|PRISM]]. - **Patent:** named inventor on [[wiki/WO2025106572A1|WO2025106572A1]]. - **Collection route:** [[collections/Neurotech|Neurotech]]. ## Sources - [E11 Bio — roadmap by Andrew Payne, 3 December 2024](https://www.e11.bio/blog/roadmap) - [E11 Bio — Andrew Payne](https://www.e11.bio/andrew-payne) ## Quotations  Quotations here are evidence for named propositions, not substitutes for proof. Confidence grades describe the quotation's provenance; they do not raise the associated scientific or philosophical inference to the same tier. The selection record is [[research/Research Inferences|Research Inferences]] and the supplied quotation review dated 2026-09-11. **Corpus context:** [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]] · [[collections/Neurotech|Neurotech]] > “even simulating our own brain circuitry.” > > — **Andrew C. Payne**, 2024 E11 Bio roadmap. [Source](https://www.e11.bio/blog/roadmap) · **Provenance confidence:** High **Evidentiary role:** articulates E11's downstream simulation horizon; it is not a claim that PRISM already performs emulation. > “build safe, brain-inspired AI, and simulate brains” > > — **Andrew C. Payne, Arlo Sheridan, Kathleen G. C. Leeper, and Johan Winnubst**, 2025 E11 Bio PRISM release. [Source](https://www.e11.bio/blog/prism) · **Provenance confidence:** High **Evidentiary role:** states the institutional motivation for detailed wiring maps while leaving demonstrated capability narrower.