# Biocompatibility **Domain:** Neural Interfaces / Biomedical Engineering **Doc Type:** Technical Constraint Node **Maturity:** Active Research and Clinical Requirement **Primary Source:** [[articles/The Art is Long|The Art is Long: Vespucci of Immortality]] **Related:** [[wiki/Longitudinal Drift|Longitudinal Drift]], [[wiki/Spatial Addressability|Spatial Addressability]], [[wiki/Invasive BCI|Invasive BCI]], [[wiki/Neural Interface|Neural Interface]] --- ## Definition **Biocompatibility** is the capacity of an implanted or tissue-coupled interface to function without producing unacceptable biological damage, inflammation, encapsulation, toxicity, or long-term loss of performance. ## Continuity Context A device that records well briefly but changes the tissue or becomes isolated from it over time is not a stable continuity instrument. Biocompatibility is therefore not a peripheral materials problem; it is a precondition for longitudinally comparable neural telemetry.