# Biological Moonshots **Entity class:** Research architecture **Domain:** Artificial intelligence / science / political economy **Maturity:** Developed ## Definition **Biological Moonshots** convert large biomedical ambitions into explicit targets that are hard to solve, easy to state, and practical to verify through standardized experiments. ## Mechanism and Consequence Targets, benchmarks, experimental harnesses, open records, and parallel AI agents turn biological discovery into an organized search process rather than an indefinite aspiration. ## Relationships - [[wiki/AI-Driven Biology|AI-Driven Biology]] - [[wiki/Accelerated Science|Accelerated Science]] - [[wiki/Age Reversal|Age Reversal]] - [[wiki/Cellular Digital Twins|Cellular Digital Twins]] ## Source Dossiers - [[research/AI Is Now So Good They Will Pay You to Quit|AI Is Now So Good They Will Pay You to Quit]] - [[research/Super Intelligence Week Index of Statements from the White House Luncheon|Super Intelligence Week Index of Statements from the White House Luncheon]] - [[research/Jensen Pushes Back on Doomers Moonshots Live|Jensen Pushes Back on Doomers Moonshots Live]] ## Simple Reminders, Quotations, and Thoughts > The Millennium Problems for Biology apply the method: pick your targets, build your harnesses, establish your benchmarks, and go. The targets include the origin of life, cryopreservation, and regrowing limbs. The proposed problems should be hard to solve but easy to verify in a standard wet lab within a couple of days. > **— Adapted from Peter Diamandis**, *MOONSHOTS Live, September 25, 2026* [[reminders/Biotechnology/Biology Needs Hard Problems That Are Easy to Verify by Peter Diamandis|Biology Needs Hard Problems That Are Easy to Verify by Peter Diamandis]] > "The beauty of the Millennium Problems for Biology is that they are easy to verify and, for now, hard to solve. That structure turns every hard biological problem into a mathematical conjecture and a target. With cellular digital twins, biology becomes a search problem, which makes it tractable for the first time in history." > **— Alexander Wissner-Gross**, *MOONSHOTS Live, September 25, 2026* [[reminders/Simulation/Cellular Digital Twins Turn Biology Into a Search Problem by Alexander Wissner-Gross|Cellular Digital Twins Turn Biology Into a Search Problem by Alexander Wissner-Gross]] > Anthropic announced that it had built its own life-science research group and wet labs. Claude, reportedly working autonomously from one prompt, searched a massive DNA database for interesting reverse transcriptases—enzymes that copy RNA or DNA. Nine hundred fifty Claude agents searched for twenty-one hours and found a repeating DNA pattern similar to CRISPR. It has been named the array-associated reverse transcriptase. Researchers do not yet know exactly what it does, but believe it may be related to programmable transcriptases and gene editing. > **— Adapted from Peter Diamandis**, *MOONSHOTS Live, September 25, 2026* [[reminders/Biotechnology/Nine Hundred Fifty AI Agents Searched DNA for New Biological Machinery by Peter Diamandis|Nine Hundred Fifty AI Agents Searched DNA for New Biological Machinery by Peter Diamandis]] > Let us have a hundred Millennium Problems for Biology, put a thousand AI agents on each one, and open-source everything they are doing. That is what the AI laboratories should collaborate on. > **— Adapted from Emad Mostaque**, *MOONSHOTS Live, September 25, 2026* [[reminders/Scientific Literacy/Put a Thousand AI Agents on Every Biological Moonshot by Emad Mostaque|Put a Thousand AI Agents on Every Biological Moonshot by Emad Mostaque]] > "Somatic limb regeneration: Demonstrate the ability to regenerate lost limbs in adult wild-type mice." > **— Edison Scientific and FutureHouse**, *MOONSHOTS Live, September 25, 2026* [[reminders/Biotechnology/Regrow Lost Limbs in Adult Mammals by Edison Scientific and FutureHouse|Regrow Lost Limbs in Adult Mammals by Edison Scientific and FutureHouse]]