# Cellular Digital Twins **Entity class:** Computational biology model **Domain:** Artificial intelligence / science / political economy **Maturity:** Developed ## Definition **Cellular Digital Twins** are computational models of cell states, responses, and transitions trained on observational and interventional biological data. ## Mechanism and Consequence Their purpose is not merely to imitate a cell but to search intervention space: begin with a diseased state, simulate candidate actions, and identify routes toward a healthy state for laboratory verification. ## Relationships - [[wiki/Digital Twin|Digital Twin]] - [[wiki/AI-Driven Biology|AI-Driven Biology]] - [[wiki/Simulation|Simulation]] - [[wiki/Biological Moonshots|Biological Moonshots]] ## Source Dossiers - [[research/AI Is Now So Good They Will Pay You to Quit|AI Is Now So Good They Will Pay You to Quit]] - [[research/Super Intelligence Week Index of Statements from the White House Luncheon|Super Intelligence Week Index of Statements from the White House Luncheon]] - [[research/Jensen Pushes Back on Doomers Moonshots Live|Jensen Pushes Back on Doomers Moonshots Live]] ## Simple Reminders, Quotations, and Thoughts > "Digital twins of cells are the critical path to solving all disease. Over the next few years, just as large language models were trained on substantially all of humanity’s behavior on the internet through text and images, we will train digital twins of all the cells in our bodies on enormous interventional and observational datasets. We will then use those cellular twins to perform exhaustive AlphaGo-like searches of intervention space, beginning with a diseased cell state and looking for a creative strategy—a Move 37—that produces a healthy cell state." > **— Alexander Wissner-Gross**, *MOONSHOTS Live, September 25, 2026* [[reminders/Simulation/Cellular Digital Twins Are the Critical Path to Solving Disease by Alexander Wissner-Gross|Cellular Digital Twins Are the Critical Path to Solving Disease by Alexander Wissner-Gross]] > "The beauty of the Millennium Problems for Biology is that they are easy to verify and, for now, hard to solve. That structure turns every hard biological problem into a mathematical conjecture and a target. With cellular digital twins, biology becomes a search problem, which makes it tractable for the first time in history." > **— Alexander Wissner-Gross**, *MOONSHOTS Live, September 25, 2026* [[reminders/Simulation/Cellular Digital Twins Turn Biology Into a Search Problem by Alexander Wissner-Gross|Cellular Digital Twins Turn Biology Into a Search Problem by Alexander Wissner-Gross]]