# Central Dogma of Molecular Biology > **Machine-Evolution Nexus:** [[articles/Digital Darwinism and the Invisible World of Machine Evolution|Digital Darwinism and the Invisible World of Machine Evolution]] places this concept within the history and governance of substrate-independent evolution. **Domain:** Molecular Biology / Information Flow **Doc Type:** Canonical Wiki Node **Maturity:** Developed ## Definition The central dogma constrains transfers of sequence information among DNA, RNA and protein; it does not claim that biological causation flows only one way. ## Machine-Evolution Context The article pairs it with von Neumann’s distinction between a passively copied description and machinery that interprets that description to construct an operative system. ## Continuity and Evidence Boundary The analogy is formal, not material identity. Cells include regulation, repair, epigenetics and environmental interaction beyond a simple tape-and-constructor picture. ## Relationships [[wiki/Francis Crick|Francis Crick]], [[wiki/DNA|DNA]], [[wiki/RNA|RNA]], [[wiki/Genotype-Phenotype Distinction|Genotype-Phenotype Distinction]] ## Sources / Provenance - Francis Crick, “On Protein Synthesis” (1958) and “Central Dogma of Molecular Biology” (1970).