# Epigenetic Modification **Domain:** Molecular Biology / Gene Regulation **Doc Type:** Scientific Concept Node **Maturity:** Established **Related:** [[Long-Term Memory Substrate]], [[Neural Plasticity]], [[RNA Editing]] --- ## Definition **Epigenetic modification** changes gene regulation through mechanisms such as DNA methylation, histone modification, chromatin remodeling, and regulatory RNA without changing the underlying DNA sequence. ## Continuity relevance Long-lived regulatory state can shape neuronal identity, plasticity, stress response, and memory-related processes. Genomic sequence alone therefore does not describe the active biological state of a brain.