H01 Connectome - Bryant McGill

# H01 Connectome **Entity class:** Concept or analytic term **Domain:** Human Connectomics / Neuroinformatics **Doc Type:** Dataset Node **Maturity:** Published partial-tissue research infrastructure **Primary Source:** [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] ## Definition The **H01 connectome** is a synapse-resolution reconstruction of a small sample of human cerebral cortex. It establishes that human cortical tissue can be imaged, segmented, proofread, and explored at petascale, while remaining a fragment rather than a whole-brain map. ## Infrastructure role H01 helped establish the shared software substrate now used across major connectomics efforts: browser-based volumetric exploration through Neuroglancer, multidimensional array access through TensorStore, and collaborative versioned proofreading through CAVE. These capabilities are routed through [[wiki/Connectome Reconstruction Infrastructure|Connectome Reconstruction Infrastructure]]. ## Comparative position - [[wiki/FlyWire|FlyWire]] supplies whole-brain completeness at insect scale. - H01 supplies human tissue at synaptic resolution but only for a small cortical volume. - [[wiki/MICrONS|MICrONS]] co-registers structure and function in mouse visual cortex. - [[wiki/ZAPBench|ZAPBench]] records whole-brain activity in larval zebrafish while aligned reconstruction proceeds. ## Evidentiary boundary Species relevance and spatial completeness are different axes. Human tissue does not make H01 person-complete, and synapse resolution does not preserve ongoing activity, molecular state, embodiment, developmental history, or autobiographical identity. ## Relationships **Related cluster nodes:** [[wiki/Connectomics|Connectomics]] · [[wiki/Connectome Reconstruction Infrastructure|Connectome Reconstruction Infrastructure]] · [[wiki/State Sufficiency Problem|State Sufficiency Problem]] · [[collections/Neurotech|Neurotech]]  This entry is routed through [[collections/Neurotech|Neurotech]] and [[collections/Consciousness Continuity|Consciousness Continuity]]. Its source context is developed in [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]], [[articles/The Architecture of Continuity and Emerging Neuroinformatics Standards|The Architecture of Continuity and Emerging Neuroinformatics Standards]], [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]], and [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]]. Status-qualified source edges are preserved in the terminal Research Edges section. ### Additional Documented Relationships - **H01 Connectome** is identified with the tooling [[wiki/Neuroglancer|Neuroglancer]]. Shared petascale visualization infrastructure. - **H01 Connectome** is identified with the tooling [[wiki/TensorStore|TensorStore]]. Petascale multidimensional array I/O.  ## Neurotech cluster route **Collection:** [[collections/Neurotech|Neurotech]] **Source articles:** [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]] · [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] ## Related Work in the Corpus  - In [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]], **IV. The brain as [[wiki/Connectomic Reference Address Space|address space]]** provides the narrative context for **H01 Connectome**: The FlyWire adult female Drosophila brain connectome established the whole-brain synaptic graph as a queryable resource at roughly 139,000 neurons. - In [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]], **Movement III — The Connectomic Substrate: Mapping the Wiring Diagram** provides the narrative context for **H01 Connectome**: Wiki route: connectomics · FlyWire · H01 · MICrONS · ZAPBench · PATHFINDER, MoGen, LICONN, and reconstruction tooling.  ## Research Edges  #### Master relationship graph patch — 2026-09-10 **Resolved aliases:** `H01` **Collection:** [[collections/Neurotech|Neurotech]] **Relationship source:** [[research/Neurotechnology Ecosystem Relationship Graph - 2026-09-10|Neurotechnology Ecosystem Relationship Graph — 2026-09-10]] **Related source articles:** [[articles/The Architecture of Continuity and Emerging Neuroinformatics Standards|The Architecture of Continuity and Emerging Neuroinformatics Standards]] · [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]] · [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] #### Outgoing typed edges - **Edge 358 — `tooling` → [[wiki/Neuroglancer|Neuroglancer]]** — **CORPUS**; evidence `CORPUS_ATLAS`. Shared petascale visualization infrastructure. - **Edge 359 — `tooling` → [[wiki/TensorStore|TensorStore]]** — **CORPUS**; evidence `CORPUS_ATLAS`. Petascale multidimensional array I/O.   #### Consciousness mapping and transfer graph patch — 2026-09-10 **Resolved aliases:** `H01` **Collections:** [[collections/Neurotech|Neurotech]] · [[collections/Consciousness Continuity|Consciousness Continuity]] **Relationship source:** [[research/Consciousness Mapping and Transfer Ecosystem Relationship Graph - 2026-09-10|Consciousness Mapping and Transfer Ecosystem Relationship Graph — 2026-09-10]] **Related source articles:** [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]] · [[articles/The Architecture of Continuity and Emerging Neuroinformatics Standards|The Architecture of Continuity and Emerging Neuroinformatics Standards]] · [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]] · [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] #### Outgoing typed edges - **Edge 358 — `tooling` → [[wiki/Neuroglancer|Neuroglancer]]** — **PRIOR_NEUROTECH_CORPUS**; evidence `CORPUS_ATLAS`. Shared petascale visualization infrastructure. - **Edge 359 — `tooling` → [[wiki/TensorStore|TensorStore]]** — **PRIOR_NEUROTECH_CORPUS**; evidence `CORPUS_ATLAS`. Petascale multidimensional array I/O.