# Intrinsic Plasticity **Domain:** Neuroscience / Cellular Excitability **Doc Type:** Scientific Concept Node **Maturity:** Established **Related:** [[Neural Plasticity]], [[Long-Term Memory Substrate]], [[Synaptic Ensemble]] --- ## Definition **Intrinsic plasticity** is lasting change in a neuron's own excitability through ion channels, thresholds, membrane properties, and cellular signaling. It changes how the neuron transforms input into output independently of changes in synaptic weight alone. ## Continuity relevance A model that reconstructs connections but not cellular response properties may preserve topology while changing circuit dynamics.