# MAGNIFY **Expanded name:** Magnify is a universal molecular anchoring strategy for expansion microscopy **Entity class:** Expansion-microscopy method **Collection:** [[collections/Neurotech|Neurotech]] **Canonical source articles:** [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]] · [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] ## Definition **MAGNIFY** is an [[wiki/Expansion Microscopy|expansion-microscopy]] strategy using a mechanically sturdy gel that retains nucleic acids, proteins, and lipids without a separate anchoring step. The original method expands diverse preserved specimens for nanoscale imaging with conventional optics. [[wiki/PRISM (E11 Bio)|PRISM]] did not invent MAGNIFY. [[wiki/Sung Yun Park|Sung Yun Park]] and [[wiki/Sven Truckenbrodt|Sven Truckenbrodt]] developed an **iterative MAGNIFY protocol** adapted to repeated staining, imaging, stripping, and registration in the PRISM workflow. ## Relationships - **Method lineage:** [[wiki/Expansion Microscopy|expansion microscopy]]. - **Adapted for PRISM by:** [[wiki/Sung Yun Park|Sung Yun Park]] and [[wiki/Sven Truckenbrodt|Sven Truckenbrodt]]. - **Component of:** [[wiki/PRISM (E11 Bio)|PRISM (E11 Bio)]]. - **Boundary:** the PRISM adaptation and the original MAGNIFY method remain distinct contributions. - **Collection route:** [[collections/Neurotech|Neurotech]]. ## Sources - [Nature Biotechnology — Magnify is a universal molecular anchoring strategy for expansion microscopy](https://doi.org/10.1038/s41587-022-01546-1) - [PubMed Central — PRISM author contributions](https://pmc.ncbi.nlm.nih.gov/articles/PMC12485930/)