Multimodal Connectomics - Bryant McGill

# Multimodal Connectomics **Entity class:** Concept or analytic term **Collection:** [[collections/Neurotech|Neurotech]] **Type:** Integrated neuroscience method **Primary sources:** [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]]; [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] ## Definition **Multimodal connectomics** combines connectivity with additional modalities such as activity, cell type, molecular markers, gene expression, or morphology in a registered coordinate system. ## Relationships - [[wiki/MICrONS|MICrONS]] combines electron-microscopy structure and calcium-imaging function. - LICONN adds molecular labeling to light-microscopy reconstruction through [[wiki/Connectome Reconstruction Infrastructure|reconstruction infrastructure]]. - Registration and provenance determine whether modalities describe the same tissue, individual, region, and time point.  This entry's documented connections are expressed in its definition and related-work routes, with provenance retained in the source-linked material.  ## Related Work in the Corpus  - In [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]], **MICrONS: Function-Structure Registration at Mammalian Scale** provides the narrative context for **Multimodal Connectomics**: The MICrONS (Machine Intelligence from Cortical Networks) program—funded by IARPA (Intelligence Advanced Research Projects Activity) and NIH—achieved the critical mammalian-scale bridge with its April 2025 Nature collection…  ## Research Inference Attractors  These are secondary semantic placements for the inference attractor network. Each statement keeps its original ID and tier; its canonical cluster page links back to every destination. Source register: [[research/Research Inferences|Research Inferences]]. Interpretive context: [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]] and [[articles/Mind Uploading and AI — The Host is Reusable and the Person is the Delta|Mind Uploading and AI — The Host is Reusable and the Person is the Delta]]. Collection route: [[collections/Neurotech|Neurotech]]. - **INF-0107 — Strongly indicated.** Electron-microscopic reconstruction of human neural tissue has already been performed on retinal and cortical samples, which means the species question is settled and the remaining question is scale. Human connectomics is underway at millimeter scale today. - **Canonical cluster:** [[wiki/Connectomics|Connectomics]] - **INF-0119 — Plausible.** Once reconstruction is automated end-to-end, connectomics becomes a service industry with throughput measured in cubic millimeters per week. Industrial throughput changes what questions get asked: comparative connectomics across individuals becomes routine, and individual variation becomes measurable. - **Canonical cluster:** [[wiki/Connectomics|Connectomics]] - **INF-0122 — Analytic.** Philanthropy funds the expensive, unprofitable middle of a capability curve that neither grants nor venture capital will carry. The existence of philanthropically funded connectomics is what keeps the mapping trajectory on schedule between public science and commercial return. - **Canonical cluster:** [[wiki/Connectomics|Connectomics]]