# Protein Structure Prediction **Domain:** Computational Biology / Machine Learning **Doc Type:** Canonical Technology Node **Maturity:** Developed ## Definition **Protein structure prediction** estimates a protein's three-dimensional structure from amino-acid sequence and other evidence. ## Evolutionary Nexus Multiple-sequence alignments expose conservation and covariation created by descent with modification. Modern learned systems can use this signal because evolution has already tested vast numbers of variants. [[articles/The Evolutionary Roots of Silicon Valley|The Evolutionary Roots of Silicon Valley]] treats the result as machine intelligence reading an evolutionary archive. ## Evidence Boundary A predicted structure is a model with confidence estimates, not a complete description of dynamics, cellular context or function. Prediction must remain connected to experimental validation. ## See Also [[wiki/Multiple Sequence Alignment|Multiple Sequence Alignment]], [[wiki/Comparative Genomics|Comparative Genomics]], [[wiki/Machine Learning|Machine Learning]], [[wiki/Scientific Inference|Scientific Inference]]