# Proteostasis **Domain:** Molecular Biology / Neuroscience **Doc Type:** Scientific Concept Node **Maturity:** Established **Related:** [[U3 Molecular Data Classes]], [[Long-Term Memory Substrate]] --- ## Definition **Proteostasis** is the regulation of protein synthesis, folding, trafficking, repair, and degradation that maintains a functional proteome. In neurons, local protein turnover and persistent molecular organization contribute to synaptic maintenance and plasticity. ## Continuity relevance A static wiring diagram may omit the molecular maintenance processes that keep synapses functional and historically conditioned. Whether and at what fidelity these processes must be captured for emulation remains an open question.