# Tahoe Therapeutics **Entity class:** Company **Domain:** Computational biology / Drug discovery **Maturity:** Developed ## Definition Tahoe Therapeutics develops large-scale perturbational single-cell data and models intended to support virtual-cell research and drug discovery. ## Mechanism and significance Its role in the broadcast is to illustrate the Bitter Lesson in biology: large interventional datasets can train general models that increasingly complement hand-built pathway knowledge. ## Relationships - **Research dossier:** [[research/ASI and RSI Timeline Research Moonshots|ASI and RSI Timeline Research Moonshots]] - **Ontology route:** [[ASI and RSI Timeline Ontology#Computational Biology and Virtual Cells|Computational Biology and Virtual Cells]] - **Primary fields:** [[AI-Driven Biology]] · [[Cellular Digital Twins]] · [[Computational Biology]] - **Adjacent concepts:** [[Whole-Cell Model]] · [[CZI Virtual Cells Platform]] · [[Massive Cellular Perturbation Study]] · [[Single-Cell Perturbation Data]] ## Sources and provenance - [[research/ASI and RSI Timeline Research Moonshots|ASI and RSI Timeline Research Moonshots]] — immediate source for this node's role in the broadcast research map. - [Tahoe Therapeutics](https://www.tahoebio.ai/) — primary organizational or project source. ## Evidence boundary The research dossier establishes why this entity or concept belongs in the Moonshots ontology. Time-sensitive organizational, product, policy, and performance claims should be checked against the linked primary source or a current authoritative source before reuse as settled fact. ## Simple Reminders, Quotations, and Thoughts > The bitter lesson is coming for biology: simple end-to-end models trained with enough data and compute can outperform elaborate collections of expert rules. Biology looks impossibly complex today, but massive perturbation studies will make increasingly useful general models possible. > **— Adapted from Richard Socher**, *MOONSHOTS Live, October 2026* [[reminders/Biotechnology/The Bitter Lesson Is Coming for Biology by Richard Socher|The Bitter Lesson Is Coming for Biology by Richard Socher]]