# Wetware Experimentation
**Entity class:** Scientific-method concept
**Domain:** Biology / Laboratory automation
**Maturity:** Developed
## Definition
Wetware experimentation is physical experimentation on living cells, tissues, organisms, or biological materials rather than purely computational evaluation.
## Mechanism and significance
For AI-driven biology, wetware closes the epistemic loop by forcing model-generated hypotheses to encounter living systems whose behavior cannot yet be simulated completely.
## Relationships
- **Research dossier:** [[research/ASI and RSI Timeline Research Moonshots|ASI and RSI Timeline Research Moonshots]]
- **Ontology route:** [[ASI and RSI Timeline Ontology#Computational Biology and Virtual Cells|Computational Biology and Virtual Cells]]
- **Primary fields:** [[AI-Driven Biology]] · [[Cellular Digital Twins]] · [[Computational Biology]]
- **Adjacent concepts:** [[Lila Sciences]] · [[Periodic Labs]] · [[Protein-State Measurement]] · [[Nondestructive Cellular Measurement]]
## Sources and provenance
- [[research/ASI and RSI Timeline Research Moonshots|ASI and RSI Timeline Research Moonshots]] — immediate source for this node's role in the broadcast research map.
## Evidence boundary
The research dossier establishes why this entity or concept belongs in the Moonshots ontology. Time-sensitive organizational, product, policy, and performance claims should be checked against the linked primary source or a current authoritative source before reuse as settled fact.