ZAPBench - Bryant McGill

# ZAPBench **Entity class:** Concept or analytic term **Domain:** Whole-Brain Activity Modeling / Functional Connectomics **Doc Type:** Dataset and Benchmark Node **Maturity:** Published activity benchmark; aligned connectome remains a separate completion claim **Primary Source:** [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] ## Definition **ZAPBench**, the Zebrafish Activity Prediction Benchmark, is a whole-brain neural-activity dataset and predictive-model benchmark based on larval zebrafish responding to controlled virtual environments. Its scale is approximately the full neuronal population of the small vertebrate brain. ## Benchmark role Models receive recent activity and are evaluated on their ability to predict held-out future neural activity. The design allows activity-only models to be compared with models that incorporate structural connectivity when the aligned connectome is available, making the value of wiring information empirically testable. ## Comparative position [[wiki/MICrONS|MICrONS]] offers dense structure-function registration in a mammalian cortical volume; ZAPBench pursues whole-brain functional coverage in a much smaller vertebrate. [[wiki/FlyWire|FlyWire]] supplies whole-brain structural completeness in an insect. These are complementary scale choices, not a single linear ranking. ## Evidentiary boundary Whole-brain recording does not equal perfect measurement, and an activity benchmark is not the same thing as a completed synapse-resolution connectome. Predicting neural dynamics supports model comparison without proving subjective experience, behavioral equivalence, or continuity. ## Relationships **Related cluster nodes:** [[wiki/Connectomics|Connectomics]] · [[wiki/Connectome Reconstruction Infrastructure|Connectome Reconstruction Infrastructure]] · [[wiki/MICrONS|MICrONS]] · [[wiki/FlyWire|FlyWire]] · [[collections/Neurotech|Neurotech]]  This entry is routed through [[collections/Neurotech|Neurotech]] and [[collections/Consciousness Continuity|Consciousness Continuity]]. Its source context is developed in [[articles/The Architecture of Continuity and Emerging Neuroinformatics Standards|The Architecture of Continuity and Emerging Neuroinformatics Standards]], [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]], [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]], and [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]]. Status-qualified source edges are preserved in the terminal Research Edges section. ### Technology and research relationships - **ZAPBench** was developed by Google Research + HHMI Janelia + Harvard University collaborators. Larval zebrafish whole-brain activity + nanoscale structure dataset. ### Key Relationships - **ZAPBench** is associated with [[wiki/Michał Januszewski|Michał Januszewski]]. ### Additional Documented Relationships - **ZAPBench** was developed by [[wiki/Google Research|Google Research]]. Larval zebrafish whole-brain activity + nanoscale structure dataset. - **ZAPBench** was developed by [[wiki/Janelia Research Campus|Janelia Research Campus]]. Larval zebrafish whole-brain activity + nanoscale structure dataset. - **ZAPBench** was developed by [[wiki/Harvard University|Harvard University]]. Larval zebrafish whole-brain activity + nanoscale structure dataset.  ## Neurotech cluster route **Collection:** [[collections/Neurotech|Neurotech]] **Source articles:** [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]] · [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] ## Related Work in the Corpus  - In [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]], **Movement III — The Connectomic Substrate: Mapping the Wiring Diagram** provides the narrative context for **ZAPBench**: Wiki route: connectomics · FlyWire · H01 · MICrONS · ZAPBench · PATHFINDER, MoGen, LICONN, and reconstruction tooling.  ## Research Edges  #### Master relationship graph patch — 2026-09-10 **Collection:** [[collections/Neurotech|Neurotech]] **Relationship source:** [[research/Neurotechnology Ecosystem Relationship Graph - 2026-09-10|Neurotechnology Ecosystem Relationship Graph — 2026-09-10]] **Related source articles:** [[articles/The Architecture of Continuity and Emerging Neuroinformatics Standards|The Architecture of Continuity and Emerging Neuroinformatics Standards]] · [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]] · [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] #### Outgoing typed edges - **Edge 356 — `developed_by` → [[wiki/Google Research|Google Research]] and [[wiki/Janelia Research Campus|Janelia Research Campus]] and [[wiki/Harvard University|Harvard University]]** — **VERIFIED**; evidence `ZAPBENCH`. Larval zebrafish whole-brain activity + nanoscale structure dataset. - **Edge 357 — `key_person` → [[wiki/Michał Januszewski|Michał Januszewski]]** — **VERIFIED**; evidence `ZAPBENCH`. Google Research connectomics.   #### Consciousness mapping and transfer graph patch — 2026-09-10 **Collections:** [[collections/Neurotech|Neurotech]] · [[collections/Consciousness Continuity|Consciousness Continuity]] **Relationship source:** [[research/Consciousness Mapping and Transfer Ecosystem Relationship Graph - 2026-09-10|Consciousness Mapping and Transfer Ecosystem Relationship Graph — 2026-09-10]] **Related source articles:** [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]] · [[articles/The Architecture of Continuity and Emerging Neuroinformatics Standards|The Architecture of Continuity and Emerging Neuroinformatics Standards]] · [[articles/2026 Annual Report on Brain-Computer Interfaces|2026 Annual Report on Brain-Computer Interfaces]] · [[articles/The Organic-Synthetic Brain Atlas|The Organic-Synthetic Brain Atlas]] #### Outgoing typed edges - **Edge 356 — `developed_by` → Google Research + HHMI Janelia + Harvard University collaborators** — **PRIOR_NEUROTECH_VERIFIED**; evidence `ZAPBENCH`. Larval zebrafish whole-brain activity + nanoscale structure dataset. - **Edge 357 — `key_person` → [[wiki/Michał Januszewski|Michał Januszewski]]** — **PRIOR_NEUROTECH_VERIFIED**; evidence `ZAPBENCH`. Google Research connectomics.  ## Research Inferences  These entries translate the forward-looking register in [[research/Research Inferences|Research Inferences]] into ordinary wiki prose. The tier labels apply to the inference, not automatically to every factual anchor inside it. The interpretive frame comes from [[articles/Technologies for Consciousness Mapping and Transfer|Technologies for Consciousness Mapping and Transfer]] and [[articles/Mind Uploading and AI — The Host is Reusable and the Person is the Delta|Mind Uploading and AI — The Host is Reusable and the Person is the Delta]]. Collection route: [[collections/Neurotech|Neurotech]]. - **INF-0127 — Strongly indicated.** Benchmarking whole-brain activity prediction in larval zebrafish turns emulation from an argument into a leaderboard. Once a capability has a benchmark, it acquires a measurable improvement rate, and measurable improvement rates end debates about feasibility.